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retinoic acid embryopathy


Definition: characteristic pattern of mental and physical birth defects that results from maternal use of retinoids, the synthetic derivatives of vitamin A, during pregnancy. The most well known retinoid is isotretinoin, a drug used to treat severe cystic acne. Features may include growth delays, malformations of the skull and facial region, and central nervous system and cardiac abnormalities.

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.