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replicative senescence

 

Definition: a limitation in the number of times that cells can divide; appears to be a basic feature of somatic cells except for most tumor cells and possibly some stem cells. The cell division s counting mechanism is posited to exist as a consequence of a telomere-shortening hypothesis.

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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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