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relapsing febrile nodular nonsuppurative panniculitis


Definition: recurrent subcutaneous nodules accompanied by fever and followed by depression of the skin on involution. The nodules show a neutrophilic lobular panniculitis with necrosis, lipid phagocytosis, and subsequent fibrosis. Most can be classified as factitious, or secondary to a1-antitrypsin deficiency, lupus profundus, pancreatic (enzymatic) fat necrosis, or cytophagic histiocytic panniculitis. Cases of undetermined cause have been called Weber-Christian disease or syndrome.

Synonym(s): Christian disease2, Weber-Christian disease

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.