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Reed-Sternberg cell

Pronunciation: rēd shtĕrn′bĕrg

Definition: large transformed lymphocytes, probably B cell in origin, generally regarded as pathognomonic of Hodgkin disease; a typical cell has a pale-staining acidophilic cytoplasm and one or two large nuclei showing marginal clumping of chromatin and unusually conspicuous deeply acidophilic nucleoli; binucleate Reed-Sternberg cell frequently shows a mirror-image form (mirror-image cell).

Synonym(s): Reed cell, Sternberg cell, Sternberg-Reed cell

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.