Definition: generally, any phenomenon in which a variable that has been displaced from its normal state by a disturbing influence temporarily deviates from normal in the opposite direction when the disturbing influence is suddenly removed, before finally stabilizing at its normal state, a phenomenon involving undershoot; the subsequent hypoglycemia that may follow injection of glucose, because the initial hyperglycemia caused excessive secretion of insulin.
Synonym(s): Stewart-Holmes sign
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Examples: glitazone, GI cocktail, etc.