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Medical Term:

reading-frameshift mutation

 

Definition: a mutation that results from insertion or deletion of a single nucleotide into, or from, the normal DNA sequence; because the genetic code is read three nucleotides at a time, all nucleotide triplets distal to the mutation will be one step out of phase and misread, and hence translated as different amino acids.

Synonym(s): addition mutation, addition-deletion mutation, deletion mutation, frameshift mutation

© Copyright 2016 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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