Definition: a scheme for substrate binding and product release for a multisubstrate enzyme; for a two-substrate two-product enzyme with this mechanism, either substrate can bind first and, after the reaction has taken place, either product can be the first to dissociate from the enzyme. Brain hexokinase has a random mechanism. More complex random mechanisms exist for enzymes having more than two substrates.
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Examples: glitazone, GI cocktail, etc.