Definition: a vaccine introduced by Pasteur as a method of treatment for the bite of a rabid animal: daily (14–21) injections of virus that increased serially from noninfective to fully infective “fixed” virus were given to render the central nervous system refractory to infection by virulent virus; this vaccine, with but slight modification (Semple vaccine), was used for many years but had the serious defect that the large quantity of heterologous nervous tissue inoculated along with the virus occasionally gave rise to an allergic (immunologic) demyelinization. It was replaced, in the case of humans, by rabies vaccine of duck embryo origin (DEV), prepared from embryonated duck eggs infected with “fixed” virus and inactivated with ß-propiolactone. At the present time DEV has been replaced by either human diploid cell vaccine (HDCV), which is grown in WI-38 cells or rabies vaccine adsorbed (RVA), which is grown in fetal Rhesus monkey cells. They both are inactivated and have a low incidence of adverse reactions and require fewer injections.
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Examples: glitazone, GI cocktail, etc.