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quinacrine hydrochloride

Pronunciation: kwin'a-kren hi'dro-klor'id

Definition: An acridine derivative, used as an antimalarial that destroys the trophozoites of Plasmodium vivax and P. falciparum but does not affect the gametocytes, sporozoites, or exoerythrocytic stage of parasites; also used as an anthelmintic. As a dihydrochloride, it is used as a stain in cytogenetics to demonstrate Y chromatin by fluorescent microscopy. Quinacrine hydrochloride intercalates with DNA and also uncouples oxidation and photophosphorylation.

Synonym(s): atabrine hydrochloride

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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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