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Pronunciation: kwin

Definition: A fluorescent compound that binds Ca++ tightly. The wavelengths of light that cause fluorescence when Ca++ is bound are longer than the wavelengths that cause fluorescence when Ca++ is not bound. When excited at two different wavelengths, the ratio of the fluorescence intensities at the two wavelengths gives the ratio of the concentrations of bound to free Ca++. Free quin-2 concentration can be measured precisely, so free Ca++ concentration can be calculated precisely. Quin-2 may be injected into cells to measure moment-to-moment changes in intracellular Ca++ concentration.

See Also: aequorin, fura-2

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.