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Medical Term:

pyruvate carboxylase


Definition: ligase catalyzing reaction of ATP, pyruvate, and HCO32-, to form ADP, orthophosphate, and oxaloacetate; biotin and acetyl-CoA are involved; an absence of this enzyme results in neuronal loss in the cerebral cortex, leading to mental retardation.

© Copyright 2016 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.