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Medical Term:

pure autonomic failure


Definition: a degenerative, sporadic neurologic disorder of adult onset, manifested principally as orthostatic hypotension and syncope, with no neurologic defects other than autonomic nervous system dysfunction evident; probably caused by selective degeneration of neurons in the sympathetic ganglia, with denervation of smooth muscle vasculature and the adrenal glands.

Synonym(s): Bradbury-Eggleston syndrome

© Copyright 2016 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.