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Pronunciation: pu'mah

Definition: [MIM*605854] a critical mediator protein involved in apoptosis induced by tumor suppressor p53 and drugs. The gene is called Puma as an acronymic construction of p53-upregulated modulator of apoptosis.

Synonym(s): Bcl2-binding component 3

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.