Definition: A glycoprotein, molecular weight approximately 72,500, formed and stored in the parenchymal cells of the liver and present in blood in a concentration of approximately 20 mg/100 mL. In the presence of thromboplastin and calcium ion, prothrombin is converted to thrombin, which in turn converts fibrinogen to fibrin, this process resulting in coagulation of blood; a deficiency of prothrombin leads to impaired blood coagulation.
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Examples: glitazone, GI cocktail, etc.