Definition: a vitamin K–dependent glycoprotein that inhibits coagulation by enzymatic cleavage of the activated forms of factors V and VIII, and thus interferes with the regulation of intravascular clot formation; a deficiency of protein C leads to impaired regulation of blood coagulation. There is an autosomal dominant deficiency [MIM*176860] that, like antithrombin III deficiency and plasminogen deficiency, is associated with an increased risk of severe or premature thrombosis.
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Examples: glitazone, GI cocktail, etc.