Definition: a single-chain, 31-kD glycoprotein with 240 amino acid residues and 4 carbohydrate side-chains; a kallikrein protease produced by prostatic epithelial cells and normally found in seminal fluid and circulating blood. Elevations of serum PSA are highly organ-specific but occur in both cancer (adenocarcinoma) and benign disease (benign prostatic hyperplasia, prostatitis). A significant number of patients with organ-confined cancer have normal PSA values.
Synonym(s): human glandular kallikrein 3
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