Definition: an enzyme that catalyzes the hydroxylation of certain prolyl residues in collagen precursors using molecular oxygen, ferrous ion, ascorbic acid, and a-ketoglutarate; a vitamin C deficiency directly affects the activity of this enzyme; one form of this enzyme (prolyl 4-hydroxylase) synthesizes 4-hydroxyprolyl residues while another produces 3-hydroxyprolyl residues.
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Examples: glitazone, GI cocktail, etc.