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progressive supranuclear palsy

 

Definition: a slowly progressive, ultimately fatal neurologic disorder with onset after the age of 40 years. Initial symptoms include difficulties in balance with repeated falls, ocular motility disturbances, slurred speech, and dysphasia; later findings include axial dystonia, supranuclear ophthalmoplegia, pseudobulbar palsy, and parkinsonism (but without tremor and with a poor response to l-dopa).

Synonym(s): Steele-Richardson-Olszewski disease, Steele-Richardson-Olszewski syndrome

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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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