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progressive spinal muscular atrophy

 

Definition: one of the subgroups of motor neuron disease; a progressive degenerative disorder of the motor neurons of the spinal cord, manifested as progressive, often symmetric, weakness and wasting, typically beginning in the distal portions of the limbs, particularly in the upper limbs, and spreading proximally; fasciculation potentials are often present, but evidence of corticospinal tract disease (increased deep tendon reflexes, Babinski sign) is not.

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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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