Definition: the best rational assessment of the probability of an outcome on the basis of established knowledge before the present experiment is performed. For instance, the prior probability of the daughter of a carrier of hemophilia being herself a carrier of hemophilia is 1/2. But if the daughter already has an affected son, the posterior probability that she is a carrier is unity, whereas if she has a normal child, the posterior probability that she is a carrier is 1/3.
See: Bayes theorem
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Examples: glitazone, GI cocktail, etc.