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primary biliary cirrhosis

 

Definition: a condition occurring mainly in middle-aged women, characterized by cholestasis with hyperlipemia, pruritus, and hyperpigmentation of the skin; no obstruction of large bile ducts or proliferation of small bile ducts is found; the liver shows cirrhosis with marked portal infiltration by lymphocytes and plasma cells, and frequently by epithelioid cell granulomas; serum antimitochondrial antibodies are present in 85–90% of patients.

Synonym(s): Hanot cirrhosis

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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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