Definition: a liver enzyme catalyzing the formation of porphobilinogen and water from two molecules of ?-aminolevulinate, an important reaction in porphyrin biosynthesis; inhibited by lead in cases of lead poisoning; a deficiency of this enzyme results in elevated levels of ?-aminolevulinate and results in neurologic disturbances.
Synonym(s): ?-aminolevulinate dehydratase
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Examples: glitazone, GI cocktail, etc.