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platelet neutralization procedure


Definition: a technique based on the ability of platelets to bypass the effect of a lupus anticoagulant by correcting prolonged coagulation times in various phospholipid-dependent test systems; the disrupted platelet membranes in the freeze-thawed platelet suspension neutralize phospholipid antibodies in the plasma of patients with lupus anticoagulant; after the patient plasma is mixed with the freeze-thawed platelet suspension, the activated partial thromboplastin time will be corrected when compared with the original baseline activated partial thromboplastin time.

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.