Definition: a relatively large, rounded or polygonal, mononuclear cell, with indistinctly or palely staining, foamlike cytoplasm that contains numerous droplets of a phosphatide, sphingomyelin; such cells are widely distributed in the spleen and other tissues, especially those rich in reticuloendothelial components, in patients with Niemann-Pick disease.
Synonym(s): Niemann-Pick cell
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