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phosphorylase kinase

 

Definition: an enzyme that uses ATP to phosphorylate phosphorylase b and thus reform phosphorylase a, the active form of phosphorylase; the active form of phosphorylase kinase is itself a phosphorylated protein; on dephosphorylation of phosphorylase kinase, the enzyme is inactivated; it can be rephosphorylated with a cAMP-dependent protein kinase; phosphorylase kinase is deficient in certain types of glycogen storage disease.

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.

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