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phosphoribosyltransferase

Pronunciation: fos'fo-ri'bo-sil-trans'fer-as

Definition: One of a group of enzymes (EC 2.4.2.x, pentosyltransferases) that transfers d-ribose 5-phosphate from 5-phospho-a-d-ribosyl pyrophosphate to a purine, pyrimidine, or pyridine acceptor, forming a 5'-nucleotide and pyrophosphate, or d-ribose from d-ribosyl phosphate to a base, forming a nucleoside, or similar pentose transfers; important in nucleotide biosynthesis. Specific phosphoribosyltransferases are preceded by the name of the acceptor base, uracil phosphoribosyltransferase (uracil + PRPP ? UMP + pyrophosphate).

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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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