Definition: an enzyme that catalyzes the hydrolysis of phosphatidylcholine (and possibly other phospholipids) to produce choline phosphate and 1,2-diacylglycerol; also acts on sphingomyelin; a key enzyme in the formation of inositol 1,4,5-trisphosphate; C. welchii and C. oedematiens ß- and ?- toxins all have phospholipase C activity.
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Examples: glitazone, GI cocktail, etc.