Definition: An isomerizing enzyme catalyzing the reversible interconversion of 2-phosphoglycerate and 3-phosphoglycerate with 2,3-bisphosphoglycerate present as a cofactor; a deficiency of this enzyme, which plays a role in glycolysis, is an inherited disorder that results in an intolerance for strenuous exercise.
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Examples: glitazone, GI cocktail, etc.