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phosphodiesterase 5 inhibitor


Definition: member of a family of phosphodiesterase inhibitors. Specifically, cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5, which breaks down cGMP and terminates its action. This is the site of action of sildenafil and similar drugs used in the treatment of erectile dysfunction.

Synonym(s): PDE5

See Also: sildenafil

Further information

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.