Pronunciation: pen-tam'i-den is'e-thi'o-nat
A toxic but effective drug for prophylaxis and treatment of early stages of both types of African sleeping sickness. It does not cross the blood-brain barrier and is not effective in the treatment of the neurologic stage of the disease. Also used to treat resistant leishmaniasis and Pneumocystis pneumonia.
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Examples: glitazone, GI cocktail, etc.