Definition: a serious form of pemphigus, occurring in middle age, in which cutaneous flaccid acantholytic suprabasal bullae and oral mucosal erosions may be localized a few months before becoming generalized; blisters break easily and are slow to heal; results from the action of autoimmune antibodies that localize to intercellular sites of stratified squamous epithelium.
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Examples: glitazone, GI cocktail, etc.