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paroxysmal nocturnal hemoglobinemia


Definition: an acquired hematopoietic stem cell disorder characterized by formation of defective platelets, granulocytes, erythrocytes, and possibly lymphocytes. The red blood cell abnormality causes complement-mediated intravascular lysis, which may be expressed in an irregular or even occult manner.

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.