Definition: a type of later tertiary syphilis, clinically manifested by progressive dementia (often with delusional systems), seizures, Argyll-Robertson pupils, dysarthria, myoclonic jerks, action tremors, generalized hyperreflexia, and Babinski signs; pathologic studies reveal a chronic frontotemporoparietal meningoencephalitis; formerly one of the major causes for insanity.
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Examples: glitazone, GI cocktail, etc.