Definition: A monoclonal immunoglobulin of blood plasma, observed electrophoretically as an intense band in ?, ß, or a regions, due to an isolated increase in a single immunoglobulin type as a result of a clone of plasma cells arising from the abnormal rapid multiplication of a single cell. The finding of a paraprotein in a patient's serum indicates the presence of a proliferating clone of immunoglobulin-producing cells and may be seen in a variety of malignant, benign, or nonneoplastic diseases.
Synonym(s): monoclonal immunoglobulin
[para + protein, fr. G. protos, first]
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Examples: glitazone, GI cocktail, etc.