A family of small, antigenically distinct viruses that replicate in nuclei of infected cells; most have oncogenic properties. Virions are 45–55 nm in diameter, nonenveloped, and ether resistant; capsids are icosahedral with 72 capsomeres, and they contain double-stranded circular DNA (MW 3–5 × 106). The family includes two genera, Papillomavirus and Polyomavirus.
[papilloma + polyoma + vacuolating]
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