Definition: the occurrence of symmetric diffuse or patchy areas of hypertrophy of the horny layer of the epidermis on the palms and soles; a group of ectodermal dysplasias of considerable variety, and either autosomal dominant or recessive inheritance.
Synonym(s): ichthyosis palmaris et plantaris, keratoderma palmare et plantare, keratoderma symmetrica, keratoma plantare sulcatum, keratosis palmaris et plantaris, tylosis palmaris et plantaris
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