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Paget disease

Pronunciation: paj'et

Definition:

  1. a generalized skeletal disease, frequently familial, of older people in which bone resorption and formation are both increased, leading to thickening and softening of bones (the skull), and bending of weight-bearing bones;
  2. a disease of elderly women, characterized by an infiltrated, somewhat eczematous lesion surrounding and involving the nipple and areola, and associated with subjacent intraductal cancer of the breast and infiltration of the lower epidermis by malignant cells;

Synonym(s): extramammary Paget disease

Synonym(s): osteitis deformans

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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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