Definition: a test useful in detecting a high-affinity hemoglobin as a cause of erythrocytosis; determines the oxygen-affinity of hemoglobin and thus limits the amount of oxygen available to tissues. Such tissue may become relatively hypoxic, which may lead to increased production of erythropoietin and to polycythemia (familial erythrocytosis).
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Examples: glitazone, GI cocktail, etc.