Definition: a painful benign neoplasm that usually originates in one of the bones of the lower extremities, especially the femur or tibia of adolescent and young adult persons; characterized by a nidus (usually no larger than 1 cm in diameter) that consists of osteoid material, vascularized osteogenic stroma, and poorly formed bone; around the nidus there is a relatively large zone of reactive thickening of the cortex.
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Examples: glitazone, GI cocktail, etc.