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orotate phosphoribosyltransferase

 

Definition: a phosphoribosyltransferase synthesizing orotidylate and pyrophosphate from orotate and 5-phospho-a-d-ribosyl-1-pyrophosphate; this enzyme is a part of pyrimidine biosynthesis; a deficiency of this enzyme is associated with orotic aciduria type I.

Synonym(s): OMP pyrophosphorylase, orotidylic acid phosphorylase, orotidylic acid pyrophosphorylase

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.

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