ordered on–random off mechanism
Definition: a scheme for substrate binding and product release for multisubstrate enzymes; for a two-substrate two-product enzyme with this mechanism, the reactants must bind to the enzyme in a distinct order; however, after the products have been formed, they may dissociate from the enzyme in either order. It has been suggested that hepatic pyruvate kinase has such a mechanism. The random on–ordered off mechanism is simply the reverse of this mechanism.
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Examples: glitazone, GI cocktail, etc.