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Pronunciation: ol'i-go-den'dro-gli-o'ma

Definition: A relatively rare, relatively slow-growing glioma derived from oligodendrocytes that occurs most frequently in the cerebrum of adult humans; the neoplasm is grossly homogeneous, fairly well circumscribed, moderately firm, and somewhat gritty in consistency with interstitial calcification sufficiently dense so as to be detected by x-ray imaging of the skull. Microscopically, an oligodendroglioma is characterized by numerous small, round or ovoid, oligodendroglial cells with small, deeply stained nuclei (rarely observed in mitosis), and palely stained, indistinct cytoplasm; the neoplastic cells are rather uniformly distributed in a sparse, fibrillary stroma with scattered calcific bodies and an often prominent arcuate vasculature; chemoresponsiveness is associated with loss of heterozygosity on chromosome 1p and 19q.

[oligo- + G. dendron, tree, + glia, + -oma]

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.