Definition: an evolutionarily conserved eukaryotic transcription factor system that contributes to the mounting of an effective immune response but also plays an important role in many other cellular processes. NF-κB and its regulators are linked to signal transduction pathways as well as transcriptional activation events that mediate critical stages of cell proliferation, development, and apoptosis.
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Examples: glitazone, GI cocktail, etc.
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