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nephritic factor


Definition: a serum protein (possibly an IgG autoantibody), found in some patients with membranoproliferative glomerulonephritis and hypocomplementemia, which, together with the cofactors of the alternate pathway of complement activation, cleaves the third component of complement (C3).

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.