A psychotomimetic agent present in several South American snuffs (cohoba snuff) and in the leaves of Prestonia amazonica (family Apocynaceae). Effects are similar to those of LSD, but with more rapid onset, greater likelihood of a panic reaction, and a shorter duration (1–2 hours). It produces pronounced autonomic effects, including a marked increase in blood pressure.
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Examples: glitazone, GI cocktail, etc.