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Pronunciation: a-sĕ′til-glū′tă-māt

Definition: The salt of N-acetylglutamic acid. An activator of carbamoyl phosphate synthetase I during urea synthesis; this amino acid causes a configurational change in the enzyme, thus increasing its activity. The inability to synthesize N-acetylglutamate results in a defect in urea biosynthesis.

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.