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myxedema

Pronunciation: miks'e-de'ma

Definition: Hypothyroidism characterized by a relatively hard edema of subcutaneous tissue, with increased content of mucins (proteoglycans) in the interstitial fluid; characterized by somnolence, slow mentation, dryness and loss of hair, increased fluid in body cavities such as the pericardial sac, subnormal temperature, hoarseness, muscle weakness, and slow return of a muscle to the neutral position after a tendon jerk; usually caused by removal or loss of functioning thyroid tissue.

[myx- + G. oidema, swelling]

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.

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