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muscarine

Pronunciation: mus'ka-ren, -rin

Definition: A toxin with neurologic effects, first isolated from Amanita muscaria (fly agaric) and also present in some species of Hebeloma and Inocybe. The quaternary trimethylammonium salt of 2-methyl-3-hydroxy-5-(aminomethyl)tetrahydrofuran, it is a cholinergic substance whose pharmacologic effects resemble those of acetylcholine and postganglionic parasympathetic stimulation (cardiac inhibition, vasodilation, salivation, lacrimation, bronchoconstriction, gastrointestinal stimulation).

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.

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