Skip to Content

moxidectin

Pronunciation: mok-se-dek'tin

Definition: An injectable macrocylic lactone antiparasitic used for control of Dirofilaria immitis heartworm and Ancylostoma caninum hookworms in heartworm-negative dogs; effect lasts 6 months; a semisynthetic avermectin class derivative of nemadectin isolated from Streptomyces cyaneogriseus noncyanogenus; less toxic in Collies then ivermectin; also used in horses as an oral gel and in cattle as topical solution; good especially for encysted small strongyles in horses. Mechanism of action is to enhance glutamate gate chloride channel permeabilty of membranes and increase gamma amino butyric acid at presynaptic membranes in nematode and arthropod nerve cells; leads to parasite paralysis and death. Not effective against flukes or tapeworms.

Disclaimer: This site is designed to offer information for general educational purposes only. The health information furnished on this site and the interactive responses are not intended to be professional advice and are not intended to replace personal consultation with a qualified physician, pharmacist, or other healthcare professional. You must always seek the advice of a professional for questions related to a disease, disease symptoms, and appropriate therapeutic treatments.
© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
Hide