Definition: the region of the cerebral cortex most nearly immediately influencing movements of the face, neck and trunk, and upper and lower extremities; it corresponds approximately to Brodmann areas 4 and 6 of the precentral gyrus and anterior paracentral gyrus, and immediately adjacent portions of the superior and middle frontal gyri; its effects on the motor neurons innervating the skeletal musculature are mediated by corticospinal fibers (pyramidal tract) and corticonuclear fibers and are particularly essential for the human capacity to perform finely graded movements of the extremities, especially the upper.
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